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The last proposed system of RBC vasodilation from the presence of nitrite would be the reduction of nitrite to NO by Hb. Brooks initially researched the nitrite Hb interaction in 1937 which do the job was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to sort metHb and NO (Brooks, 1937; Doyle